Menopause and Breast Cancer Risk. How Breast Cancer and Menopause Are Related
Menopause is a natural part of ageing when you stop having monthly periods, usually between the ages of 45 and 55.
If you are over the age of 50 and have been through menopause, you have a higher risk of breast cancer.
In post-menopause, things that increase your risk of breast cancer include reaching menopause after the age of 55, being overweight or obese, having type 2 diabetes, and taking hormone replacement therapy (HRT).
HRT is used to manage the symptoms of menopause and has been associated with an increased risk of developing breast cancer. Your risk varies according to the type of HRT and duration of use.
What effect does menopause have on my breast cancer risk?
Menopause does not cause breast cancer. Yet, your risk of developing breast cancer increases with age. It is most common in people over the age of 50 who have been through menopause (8 out of 10 cases) compared to other age brackets.
As you age, mutations can potentially build up in your cells, including those that may increase your risk of breast cancer. Also, post-menopause, oestrogen is mainly produced by fat tissue, which makes up a week bigger proportion of your breast. This means the levels of oestrogen in your breast can be higher, which may increase your risk of breast cancer.
What factors increase my breast cancer risk after menopause?
If you reach menopause after the age of 55, you have a higher risk of breast cancer. Your risk is higher if you also started your periods before the age of 12. This may be due to a more prolonged exposure to oestrogen circulating in your body.
Having higher levels of naturally circulating sex hormones (oestrogen, progesterone and testosterone) increases your breast cancer risk. Post-menopausal individuals with higher levels of naturally circulating oestrogen have around twice the risk of breast cancer compared to those with lower levels.
Being overweight or obese after reaching menopause is a significant risk factor for breast cancer, and your risk increases the more weight you gain. A UK study found that post-menopausal women who were obese had a 30% higher risk of breast cancer compared to those of a healthy weight.
Type 2 diabetes increases your risk of breast cancer, particularly post-menopause. However, the reason behind this is not completely understood.
Does HRT increase my breast cancer risk?
Hormone replacement therapy (HRT) is used to manage the symptoms of menopause by replacing either the sex hormones oestrogen and progesterone or just oestrogen. It has been associated with an increased risk of breast cancer. However, your risk depends on the type of HRT you take and the duration of use.
With oestrogen-only HRT, there is little to no increased risk of breast cancer. This type of HRT is usually only recommended to people who have had their uterus removed (hysterectomy).
Combined HRT, which consists of taking a combination of both oestrogen and progestogen, may increase your breast cancer risk when used over five years. Your risk reduces after you stop taking the combined HRT treatment. But some risk remains if used for over ten years.
The decision to take HRT is your individual choice, made in consultation with your qualified healthcare professional based on personal symptoms.
What is the menopause? Premenstrual Syndrome -
Women start perimenopause at different ages. You may notice signs of progression toward menopause, such as menstrual irregularity, sometime in your 40s. But some women notice changes as early as their mid-30s.
Perimenopause means "around menopause" and refers to the time during which your body makes the natural transition to menopause, marking the end of the reproductive years. Perimenopause is also called the menopausal transition.
The level of estrogen — the main female hormone — in your body rises and falls unevenly during perimenopause. Your menstrual cycles may lengthen or shorten, and you may begin having menstrual cycles in which your ovaries don't release an egg (ovulate). You may also experience menopause-like symptoms, such as hot flashes, sleep problems and vaginal dryness. Treatments are available to help ease these symptoms.
Once you've gone through 12 consecutive months without a menstrual period, you've officially reached menopause, and the perimenopause period is over.
🔸Irregular periods. As ovulation becomes more unpredictable, the length of time between periods may be longer or shorter, your flow may be light to heavy, and you may skip some periods. If you have a persistent change of seven days or more in the length of your menstrual cycle, you may be in early perimenopause. If you have a space of 60 days or more between periods, you're likely in late perimenopause.
🔸Hot flashes and sleep problems. Hot flashes are common during perimenopause. The intensity, length and frequency vary.
🔸Sleep problems are often due to hot flashes or night sweats, but sometimes sleep becomes unpredictable even without them.
🔸Mood changes. Mood swings, irritability or increased risk of depression may happen during perimenopause. The cause of these symptoms may be sleep disruption associated with hot flashes. Mood changes may also be caused by factors not related to the hormonal changes of perimenopause.
🔸Vaginal and bladder problems. When estrogen levels diminish, your vaginal tissues may lose lubrication and elasticity, making intercourse painful. Low estrogen may also leave you more vulnerable to urinary or vaginal infections. Loss of tissue tone may contribute to urinary incontinence.
🔸Decreasing fertility. As ovulation becomes irregular, your ability to conceive decreases. However, as long as you're having periods, pregnancy is still possible. If you wish to avoid pregnancy, use birth control until you've had no periods for 12 months.
🔸Changes in sexual function. During perimenopause, sexual arousal and desire may change. But if you had satisfactory sexual intimacy before menopause, this will likely continue through perimenopause and beyond.
🔸Loss of bone. With declining estrogen levels, you start to lose bone more quickly than you replace it, increasing your risk of osteoporosis — a disease that causes fragile bones.
🔸Changing cholesterol levels. Declining estrogen levels may lead to unfavorable changes in your blood cholesterol levels, including an increase in low-density lipoprotein (LDL) cholesterol — the "bad" cholesterol — which contributes to an increased risk of heart disease. At the same time, high-density lipoprotein (HDL) cholesterol — the "good" cholesterol — decreases in many women as they age, which also increases the risk of heart disease.
When to see a doctor
Some women seek medical attention for their perimenopausal symptoms. But others either tolerate the changes or simply don't experience symptoms severe enough to need attention. Because symptoms may be subtle and come on gradually, you may not realize at first that they're all connected to the same thing — hormone fluctuations of the menopausal transition.
If you have symptoms that interfere with your life or well-being, such as
🔸hot flashes,
🔸mood swings or
🔸changes in sexual function that concern you, see your doctor.
As you go through perimenopause, your body's production of estrogen and progesterone, key female hormones, rises and falls. Many of the changes you experience during perimenopause are a result of decreasing estrogen.
Risk factors
Menopause is a normal phase in life. But it may occur earlier in some women than in others. Although not always conclusive, some evidence suggests that certain factors may make it more likely that you start perimenopause at an earlier age, including:
🔸Smoking. The onset of menopause occurs 1 to 2 years earlier in women who smoke than in women who don't smoke.
🔸Family history. Women with a family history of early menopause may experience early menopause themselves.
🔸Cancer treatment. Treatment for cancer with chemotherapy or pelvic radiation therapy has been linked to early menopause.
🔸Hysterectomy. A hysterectomy that removes your uterus, but not your ovaries, usually doesn't cause menopause. Although you no longer have periods, your ovaries still produce estrogen. But such surgery may cause menopause to occur earlier than average. Also, if you have one ovary removed, the remaining ovary might stop working sooner than expected.
Complications
Irregular periods are a hallmark of perimenopause. Most of the time this is normal and nothing to be concerned about. However, see your doctor if:
🔸Bleeding is extremely heavy — you're changing tampons or pads every hour or two for two or more hours
🔸Bleeding lasts longer than seven days
🔸Bleeding occurs between periods
🔸Periods regularly occur less than 21 days apart
Signs such as these may mean there's a problem with your reproductive system that requires diagnosis and treatment.
Menopause is associated with a substantial and rapid decline in ovarian hormone production. Early age at menopause is a protective risk factor for breast cancer. In descriptive epidemiology, see a slowing of the age-related rising trend in breast cancer risk after menopause. Simply put, the use of HRT might keep the woman in a de-facto premenopausal state, and she does not have the benefit of menopause on cancer risk reduction.
You can manage your menopause symptoms by:
🔸 Using Lavender Dreamy Detoxification -
Be evergreen in Menopause , improve reproductive system & balanced vaginal dryness.
🔸 Regular physical activity
🔸A healthy diet
🔸Staying in cool places and wearing loose, cool clothes
🔸Limiting alcohol, caffeine, and peppers
🔸Managing your stress levels
🔸Using lubricants if you experience vaginal dryness.
Breast Self-Exam should be carried out once a month after a period has finished, for women who’ve already finished the Menopause https://cgd-sharia.blogspot.com/2020/10/breast-self-exam-should-be-carried-out.html
Menopause/menopausal symptoms in women with breast cancer have a significant negative impact on quality of life, with both short- and long-term health consequences, and can affect BC treatment adherence. Management of menopause in women with breast cancer is directed at relieving troublesome symptoms and minimizing risks of cardiovascular disease, osteoporosis and breast cancer recurrence.
References:
The Lancet ,Breast Cancer UK , Australasian Menopause Society, Breast Cancer.org, WebMD, National Institute of Health, American Cancer Society
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